CATH Classification

Domain Context

CATH Clusters

Superfamily Taq DNA Polymerase; Chain T, domain 4
Functional Family DNA-directed DNA polymerase

Enzyme Information

3.1.11.-
Exodeoxyribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P00581
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P00581
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (2)

P0AA25
THIO_ECOLI
Escherichia coli K-12
Thioredoxin 1
P00581
DPOL_BPT7
Enterobacteria phage T7
DNA-directed DNA polymerase

PDB Structure

PDB 1X9M
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis.
Dutta, S., Li, Y., Johnson, D., Dzantiev, L., Richardson, C.C., Romano, L.J., Ellenberger, T.
Proc.Natl.Acad.Sci.USA