CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.160.20
Functional Family Eukaryotic translation initiation factor 2-alpha kinase 2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q03963
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q03963
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q03963
E2AK2_MOUSE
Mus musculus
Interferon-induced, double-stranded RNA-activated protein kinase

PDB Structure

PDB 1X49
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the first DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase
He, F., Muto, Y., Inoue, M., Kigawa, T., Shirouzu, M., Terada, T., Yokoyama, S.
To be Published