CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Carbonyl reductase [NADPH] 1 |
Enzyme Information
| 1.1.1.189 |
Prostaglandin-E(2) 9-reductase.
based on mapping to UniProt P16152
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
-!- Reduces prostaglandin E(2) to prostaglandin F(2)-alpha. -!- A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. -!- May be identical with EC 1.1.1.197.
|
| 1.1.1.197 |
15-hydroxyprostaglandin dehydrogenase (NADP(+)).
based on mapping to UniProt P16152
(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)- 11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.
-!- Acts on prostaglandins E(2), F(2)-alpha and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.141 and EC 1.1.1.196). -!- May be identical with EC 1.1.1.189.
|
| 1.1.1.184 |
Carbonyl reductase (NADPH).
based on mapping to UniProt P16152
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
-!- Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol. -!- Si-specific with respect to NADPH (cf. EC 1.1.1.2).
|
UniProtKB Entries (1)
| P16152 |
CBR1_HUMAN
Homo sapiens
Carbonyl reductase [NADPH] 1
|
PDB Structure
| PDB | 1WMA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
An unbiased cell morphology-based screen for new, biologically active small molecules
Plos Biol.
|