CATH Classification

Domain Context

CATH Clusters

Superfamily Coagulation Factor IX
Functional Family

Enzyme Information

3.4.21.6
Coagulation factor Xa.
based on mapping to UniProt P00743
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
-!- A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. -!- Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. -!- The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids. -!- Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00743
FA10_BOVIN
Bos taurus
Coagulation factor X

PDB Structure

PDB 1WHE
External Links
Method SOLUTION NMR
Organism
Primary Citation
The relative orientation of Gla and EGF domains in coagulation factor X is altered by Ca2+ binding to the first EGF domain. A combined NMR-small angle X-ray scattering study.
Sunnerhagen, M., Olah, G.A., Stenflo, J., Forsen, S., Drakenberg, T., Trewhella, J.
Biochemistry