CATH Classification

Domain Context

CATH Clusters

Superfamily Trigger factor ribosome-binding domain
Functional Family Trigger factor

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P0A850
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P0A850
TIG_ECOLI
Escherichia coli K-12
Trigger factor

PDB Structure

PDB 1W26
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Trigger Factor in Complex with the Ribosome Forms a Molecular Cradle for Nascent Proteins
Ferbitz, L., Maier, T., Patzelt, H., Bukau, B., Deuerling, E., Ban, N.
Nature