CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.270
Functional Family Response regulator PleD

Enzyme Information

2.7.7.65
Diguanylate cyclase.
based on mapping to UniProt B8GZM2
2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate.
-!- Can be activated by BeF3, a phosphoryl mimic, which results in dimerization. -!- Dimerization is required but is not sufficient for diguanylate- cyclase activity. -!- Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.

UniProtKB Entries (1)

B8GZM2
PLED_CAUVN
Caulobacter vibrioides NA1000
Response regulator PleD

PDB Structure

PDB 1W25
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of Activity and Allosteric Control of Diguanylate Cyclase
Chan, C., Paul, R., Samoray, D., Amiot, N., Giese, B., Jenal, U., Schirmer, T.
Proc.Natl.Acad.Sci.USA