CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P0AFL3
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P0AFL3
PPIA_ECOLI
Escherichia coli K-12
Peptidyl-prolyl cis-trans isomerase A

PDB Structure

PDB 1V9T
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Escherichia coli cyclophilin B binds a highly distorted form of trans-prolyl peptide isomer
Konno, M., Sano, Y., Okudaira, K., Kawaguchi, Y., Yamagishi-Ohmori, Y., Fushinobu, S., Matsuzawa, H.
Eur.J.Biochem.