CATH Classification

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

Enzyme Information

2.4.1.135
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase.
based on mapping to UniProt Q9P2W7
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D- galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.
-!- Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates).

UniProtKB Entries (1)

Q9P2W7
B3GA1_HUMAN
Homo sapiens
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

PDB Structure

PDB 1V83
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Basis for Acceptor Substrate Recognition of a Human Glucuronyltransferase, GlcAT-P, an Enzyme Critical in the Biosynthesis of the Carbohydrate Epitope HNK-1
Kakuda, S., Shiba, T., Ishiguro, M., Tagawa, H., Oka, S., Kajihara, Y., Kawasaki, T., Wakatsuki, S., Kato, R.
J.Biol.Chem.