CATH Classification

Domain Context

CATH Clusters

Superfamily Alkaline Phosphatase, subunit A
Functional Family Alkaline phosphatase

Enzyme Information

3.1.3.1
Alkaline phosphatase.
based on mapping to UniProt P00634
A phosphate monoester + H(2)O = an alcohol + phosphate.
-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).

UniProtKB Entries (1)

P00634
PPB_ECOLI
Escherichia coli K-12
Alkaline phosphatase

PDB Structure

PDB 1URA
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Kinetic and structural consequences of replacing the aspartate bridge by asparagine in the catalytic metal triad of Escherichia coli alkaline phosphatase.
Tibbitts, T.T., Murphy, J.E., Kantrowitz, E.R.
J.Mol.Biol.