CATH Classification

Domain Context

CATH Clusters

Superfamily POLO box domain
Functional Family Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21
Polo kinase.
based on mapping to UniProt P53350
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P53350
PLK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase PLK1

PDB Structure

PDB 1UMW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain
Elia, A., Rellos, P., Haire, L., Chao, J., Ivins, F., Hoepker, K., Mohammad, D., Cantley, L., Smerdon, S.J., Yaffe, M.B.
Cell(Cambridge,Mass.)