CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00735
THRB_BOVIN
Bos taurus
Prothrombin

PDB Structure

PDB 1UCY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues.
Martin, P.D., Malkowski, M.G., DiMaio, J., Konishi, Y., Ni, F., Edwards, B.F.
Biochemistry