CATH Classification

Domain Context

CATH Clusters

Superfamily PCRA; domain 4
Functional Family ATP-dependent DNA helicase Rep

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P09980
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P09980
REP_ECOLI
Escherichia coli K-12
ATP-dependent DNA helicase Rep

PDB Structure

PDB 1UAA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP.
Korolev, S., Hsieh, J., Gauss, G.H., Lohman, T.M., Waksman, G.
Cell(Cambridge,Mass.)