CATH Classification

Domain Context

CATH Clusters

Functional Family 3-oxoacyl-[acyl-carrier-protein] synthase 3

Enzyme Information
Beta-ketoacyl-[acyl-carrier-protein] synthase III.
based on mapping to UniProt P9WNG3
Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier- protein] + CoA + CO(2).
-!- Involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. -!- In contrast to EC and EC, this enzyme specifically uses CoA thioesters rather than acyl-ACP as the primer. -!- In addition to the above reaction, the enzyme can also catalyze the reaction of EC, but to a much lesser extent. -!- Responsible for initiating both straight- and branched-chain fatty- acid biosynthesis, with the substrate specificity in an organism reflecting the fatty-acid composition found in that organism. -!- For example, Streptococcus pneumoniae, a Gram-positive bacterium, is able to use both straight- and branched-chain (C4--C6) acyl-CoA primers whereas Escherichia coli, a Gram-negative organism, uses primarily short straight-chain acyl CoAs, with a preference for acetyl-CoA.

UniProtKB Entries (1)

Mycobacterium tuberculosis H37Rv
3-oxoacyl-[acyl-carrier-protein] synthase 3

PDB Structure

External Links
Organism Escherichia
Primary Citation
Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A.
Musayev, F., Sachdeva, S., Scarsdale, J.N., Reynolds, K.A., Wright, H.T.