CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.520.10
Functional Family Catalase-peroxidase

Enzyme Information

1.11.1.21
Catalase peroxidase.
based on mapping to UniProt P13029
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

UniProtKB Entries (1)

P13029
KATG_ECOLI
Escherichia coli K-12
Catalase-peroxidase

PDB Structure

PDB 1U2J
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the C-terminal domain of the catalase-peroxidase KatG from Escherichia coli.
Carpena, X., Melik-Adamyan, W., Loewen, P.C., Fita, I.
Acta Crystallogr.,Sect.D