CATH Classification

Domain Context

CATH Clusters

Superfamily 3.20.20.210
Functional Family 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Enzyme Information

2.1.1.14
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
based on mapping to UniProt O50008
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.
-!- Requires phosphate. -!- The enzyme from Escherichia coli also requires a reducing system. -!- Unlike EC 2.1.1.13 this enzyme does not contain cobalamin.

UniProtKB Entries (1)

O50008
METE1_ARATH
Arabidopsis thaliana
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1

PDB Structure

PDB 1U22
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate
Ferrer, J.-L., Ravanel, S., Robert, M., Dumas, R.
J.Biol.Chem.