CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.40
Functional Family

Enzyme Information

2.7.2.1
Acetate kinase.
based on mapping to UniProt P38502
ATP + acetate = ADP + acetyl phosphate.
-!- While purified enzyme from Escherichia coli is specific for acetate, others have found that the enzyme can also use propanoate as a substrate, but more slowly. -!- Acetate can be converted into the key metabolic intermediate acetyl- CoA by coupling acetate kinase with EC 2.3.1.8. -!- Both this enzyme and EC 2.7.2.15 play important roles in the production of propanoate.

UniProtKB Entries (1)

P38502
ACKA_METTE
Methanosarcina thermophila
Acetate kinase

PDB Structure

PDB 1TUY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and Kinetic Analyses of Arginine Residues in the Active Site of the Acetate Kinase from Methanosarcina thermophila.
Gorrell, A., Lawrence, S.H., Ferry, J.G.
J.Biol.Chem.