CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P56409
ORNT_ORNMO
Ornithodoros moubata
Ornithodorin
P00735
THRB_BOVIN
Bos taurus
Prothrombin

PDB Structure

PDB 1TOC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The ornithodorin-thrombin crystal structure, a key to the TAP enigma?
van de Locht, A., Stubbs, M.T., Bode, W., Friedrich, T., Bollschweiler, C., Hoffken, W., Huber, R.
EMBO J.