CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92
Endopeptidase Clp.
based on mapping to UniProt Q16740
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

Q16740
CLPP_HUMAN
Homo sapiens
ATP-dependent Clp protease proteolytic subunit, mitochondrial

PDB Structure

PDB 1TG6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP
Kang, S.G., Maurizi, M.R., Thompson, M., Mueser, T., Ahvazi, B.
J.Struct.Biol.