CATH Classification

Domain Context

CATH Clusters

Superfamily 3.20.20.210
Functional Family

Enzyme Information

2.1.1.14
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
based on mapping to UniProt Q9X112
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.
-!- Requires phosphate. -!- The enzyme from Escherichia coli also requires a reducing system. -!- Unlike EC 2.1.1.13 this enzyme does not contain cobalamin.

UniProtKB Entries (1)

Q9X112
METE_THEMA
Thermotoga maritima MSB8
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

PDB Structure

PDB 1T7L
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication
Pejchal, R., Ludwig, M.L.
Plos Biol.