CATH Classification

Domain Context

CATH Clusters

Superfamily ligand-binding face of the semaphorins, domain 2
Functional Family

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P08581
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581
MET_HUMAN
Homo sapiens
Hepatocyte growth factor receptor

PDB Structure

PDB 1SSL
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Insights into function of PSI domains from structure of the Met receptor PSI domain.
Kozlov, G., Perreault, A., Schrag, J.D., Park, M., Cygler, M., Gehring, K., Ekiel, I.
Biochem.Biophys.Res.Commun.