CATH Classification

Domain Context

CATH Clusters

Superfamily DNA-directed RNA polymerase, beta subunit, external 1 domain
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q8RQE9
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q5SHR6
RPOA_THET8
Thermus thermophilus HB8
DNA-directed RNA polymerase subunit alpha

PDB Structure

PDB 1SMY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for transcription regulation by alarmone ppGpp
Artsimovitch, I., Patlan, V., Sekine, S., Vassylyeva, M.N., Hosaka, T., Ochi, K., Yokoyama, S., Vassylyev, D.G.
Cell(Cambridge,Mass.)