CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.140.60
Functional Family Calmodulin-sensitive adenylate cyclase

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt P40136
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (2)

P40136
CYAA_BACAN
Bacillus anthracis
Calmodulin-sensitive adenylate cyclase
P0DP25
CALM3_HUMAN
Homo sapiens
Calmodulin-3

PDB Structure

PDB 1SK6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.
Guo, Q., Shen, Y., Zhukovskaya, N.L., Florian, J., Tang, W.J.
J.Biol.Chem.