CATH Classification

Domain Context

CATH Clusters

Superfamily Regulator of G-protein Signalling 4, domain 2
Functional Family Rho guanine nucleotide exchange factor 1

Enzyme Information

UniProtKB Entries (3)

P10824
GNAI1_RAT
Rattus norvegicus
Guanine nucleotide-binding protein G(i) subunit alpha-1
P27601
GNA13_MOUSE
Mus musculus
Guanine nucleotide-binding protein subunit alpha-13
Q92888
ARHG1_HUMAN
Homo sapiens
Rho guanine nucleotide exchange factor 1

PDB Structure

PDB 1SHZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator.
Chen, Z., Singer, W.D., Sternweis, P.C., Sprang, S.R.
Nat.Struct.Mol.Biol.