CATH Classification

Domain Context

CATH Clusters

Superfamily 2.60.120.20
Functional Family Genome polyprotein

Enzyme Information

2.7.7.48
RNA-directed RNA polymerase.
based on mapping to UniProt P03303
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.4.22.28
Picornain 3C.
based on mapping to UniProt P03303
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
-!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
3.6.1.15
Nucleoside-triphosphate phosphatase.
based on mapping to UniProt P03303
NTP + H(2)O = NDP + phosphate.
-!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
3.4.22.29
Picornain 2A.
based on mapping to UniProt P03303
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein.
-!- From entero- and rhinoviruses. -!- Smaller than the homologous virus picornain 3C. -!- Belongs to peptidase family C3.

UniProtKB Entries (2)

Q8K1F2
Q8K1F2_MOUSE
Mus musculus
Anti-VIPase light chain variable region
P03303
POLG_HRV14
Rhinovirus B14
Genome polyprotein

PDB Structure

PDB 1RVF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon.
Smith, T.J., Chase, E.S., Schmidt, T.J., Olson, N.H., Baker, T.S.
Nature