CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family Geranylgeranyl diphosphate synthase

Enzyme Information

2.5.1.10
(2E,6E)-farnesyl diphosphate synthase.
based on mapping to UniProt P22939
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate.
-!- Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. -!- The enzyme will not accept larger prenyl diphosphates as efficient donors.

UniProtKB Entries (1)

P22939
ISPA_ECOLI
Escherichia coli K-12
Farnesyl diphosphate synthase

PDB Structure

PDB 1RQJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
Hosfield, D.J., Zhang, Y., Dougan, D.R., Brooun, A., Tari, L.W., Swanson, R.V., Finn, J.
J.Biol.Chem.