CATH Classification

Domain Context

CATH Clusters

Superfamily Lyase 2-enoyl-coa Hydratase, Chain A, domain 2
Functional Family 1,4-dihydroxy-2-naphthoyl-CoA synthase

Enzyme Information

4.1.3.36
1,4-dihydroxy-2-naphthoyl-CoA synthase.
based on mapping to UniProt P9WNP5
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O.
-!- This enzyme is involved in the synthesis of 1,4-dihydroxy-2- naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K(2), in bacteria), phylloquinone (vitamin K(1) in plants), and many plant pigments. -!- The coenzyme A group is subsequently removed from the product by EC 3.1.2.28.

UniProtKB Entries (1)

P9WNP5
MENB_MYCTU
Mycobacterium tuberculosis H37Rv
1,4-dihydroxy-2-naphthoyl-CoA synthase

PDB Structure

PDB 1RJN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Crystal Structure of MenB (Rv0548c) from Mycobacterium tuberculosis in Complex with the CoA Portion of Naphthoyl CoA
Johnston, J.M., Arcus, V.L., Baker, E.N.
To be Published