CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Leucine carboxyl methyltransferase 1

Enzyme Information

2.1.1.233
[Phosphatase 2A protein]-leucine-carboxy methyltransferase.
based on mapping to UniProt Q04081
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl- L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.
-!- Methylates the C-terminal leucine of phosphatase 2A. -!- A key regulator of protein phosphatase 2A. -!- The methyl ester is hydrolyzed by EC 3.1.1.89. -!- Occurs mainly in the cytoplasm, Golgi region and late endosomes.

UniProtKB Entries (1)

Q04081
LCMT1_YEAST
Saccharomyces cerevisiae S288C
Leucine carboxyl methyltransferase 1

PDB Structure

PDB 1RJD
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity
Leulliot, N., Quevillon-Cheruel, S., Sorel, I., Li de La Sierra-Gallay, I., Collinet, B., Graille, M., Blondeau, K., Bettache, N., Poupon, A., Janin, J., van Tilbeurgh, H.
J.Biol.Chem.