CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Protein-L-isoaspartate O-methyltransferase

Enzyme Information

2.1.1.77
Protein-L-isoaspartate(D-aspartate) O-methyltransferase.
based on mapping to UniProt Q27869
S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L- homocysteine + protein L-isoaspartate alpha-methyl ester.
-!- D-aspartate (but not L-aspartate) residues in proteins can also act as acceptors. -!- Formerly EC 2.1.1.24.

UniProtKB Entries (1)

Q27869
PIMT_DROME
Drosophila melanogaster
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

PDB Structure

PDB 1R18
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Catalytic implications from the Drosophila protein L-isoaspartyl methyltransferase structure and site-directed mutagenesis.
Bennett, E.J., Bjerregaard, J., Knapp, J.E., Chavous, D.A., Friedman, A.M., Royer Jr., W.E., O'Connor, C.M.
Biochemistry