CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Enoyl-[acyl-carrier-protein] reductase [NADH]

Enzyme Information

1.3.1.9
Enoyl-[acyl-carrier-protein] reductase (NADH).
based on mapping to UniProt P0AEK4
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.
-!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.

UniProtKB Entries (1)

P0AEK4
FABI_ECOLI
Escherichia coli K-12
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

PDB Structure

PDB 1QSG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis and mechanism of enoyl reductase inhibition by triclosan.
Stewart, M.J., Parikh, S., Xiao, G., Tonge, P.J., Kisker, C.
J.Mol.Biol.