CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1970
Functional Family N5-carboxyaminoimidazole ribonucleotide mutase

Enzyme Information

5.4.99.18
5-(carboxyamino)imidazole ribonucleotide mutase.
based on mapping to UniProt P0AG18
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate.
-!- In eubacteria, fungi and plants, this enzyme, along with EC 6.3.4.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates. -!- In the absence of EC 6.3.2.6, the reaction is reversible. -!- The substrate is readily converted into 5-amino-1-(5-phospho-D- ribosyl)imidazole by non-enzymic decarboxylation.

UniProtKB Entries (1)

P0AG18
PURE_ECOLI
Escherichia coli K-12
N5-carboxyaminoimidazole ribonucleotide mutase

PDB Structure

PDB 1QCZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.
Mathews, I.I., Kappock, T.J., Stubbe, J., Ealick, S.E.
Structure Fold.Des.