CATH Classification

Domain Context

CATH Clusters

Superfamily Poly(A) polymerase predicted RNA binding domain
Functional Family Putative poly(A) polymerase gamma

Enzyme Information

2.7.7.19
Polynucleotide adenylyltransferase.
based on mapping to UniProt P25500
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

P25500
PAPOA_BOVIN
Bos taurus
Poly(A) polymerase alpha

PDB Structure

PDB 1Q79
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase.
Martin, G., Moglich, A., Keller, W., Doublie, S.
J.Mol.Biol.