CATH Classification

Domain Context

CATH Clusters

Superfamily Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Functional Family

Enzyme Information

6.3.3.6
Carbapenam-3-carboxylate synthase.
based on mapping to UniProt Q9XB61
ATP + (2S,5S)-5-carboxymethylproline = AMP + diphosphate + (3S,5S)- carbapenam 3-carboxylate.
-!- The enzyme is involved in the biosynthesis of the carbapenem beta- lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. -!- Formerly EC 6.3.1.16.

UniProtKB Entries (1)

Q9XB61
CARA_PECCC
Pectobacterium carotovorum subsp. carotovorum
Carbapenam-3-carboxylate synthase

PDB Structure

PDB 1Q19
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Carbapenam Synthetase (CarA)
Miller, M.T., Gerratana, B., Stapon, A., Townsend, C.A., Rosenzweig, A.C.
J.Biol.Chem.