CATH Classification

Domain Context

CATH Clusters

Superfamily Adenine-specific Methyltransferase, Domain 2
Functional Family

Enzyme Information

2.1.1.72
Site-specific DNA-methyltransferase (adenine-specific).
based on mapping to UniProt P04392
S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA.
-!- This is a large group of enzymes, most of which form so-called 'restriction-modification systems', with nucleases that possess similar site specificity (the nucleases are listed as either EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5). -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P04392
DMA_BPT4
Escherichia virus T4
DNA adenine methylase

PDB Structure

PDB 1Q0T
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the bacteriophage T4 DNA adenine methyltransferase
Yang, Z., Horton, J.R., Zhou, L., Zhang, X.J., Dong, A., Zhang, X., Schlagman, S.L., Kossykh, V., Hattman, S., Cheng, X.
Nat.Struct.Biol.