CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family

Enzyme Information

2.4.2.1
Purine-nucleoside phosphorylase.
based on mapping to UniProt P00491
(1) Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. (2) Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.
-!- Specificity not completely determined. -!- Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5.

UniProtKB Entries (1)

P00491
PNPH_HUMAN
Homo sapiens
Purine nucleoside phosphorylase

PDB Structure

PDB 1PWY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir.
dos Santos, D.M., Canduri, F., Pereira, J.H., Vinicius Bertacine Dias, M., Silva, R.G., Mendes, M.A., Palma, M.S., Basso, L.A., de Azevedo, W.F., Santos, D.S.
Biochem.Biophys.Res.Commun.