CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Thiopurine S-methyltransferase |
Enzyme Information
| 2.1.1.67 |
Thiopurine S-methyltransferase.
based on mapping to UniProt O86262
S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.
-!- Also acts, more slowly, on thiopyrimidines and aromatic thiols. -!- Not identical with EC 2.1.1.9.
|
UniProtKB Entries (1)
| O86262 |
TPMT_PSESJ
Pseudomonas syringae pv. pisi
Thiopurine S-methyltransferase
|
PDB Structure
| PDB | 1PJZ |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme
J.Mol.Biol.
|