CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Indole-3-glycerol phosphate synthase

Enzyme Information

4.1.1.48
Indole-3-glycerol-phosphate synthase.
based on mapping to UniProt P00909
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C- (3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).
5.3.1.24
Phosphoribosylanthranilate isomerase.
based on mapping to UniProt P00909
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1- deoxy-D-ribulose 5-phosphate.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.1.48, EC 4.1.3.27 and EC 4.2.1.20).

UniProtKB Entries (1)

P00909
TRPC_ECOLI
Escherichia coli K-12
Tryptophan biosynthesis protein TrpCF

PDB Structure

PDB 1PII
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from Escherichia coli refined at 2.0 A resolution.
Wilmanns, M., Priestle, J.P., Niermann, T., Jansonius, J.N.
J.Mol.Biol.