CATH Classification

Domain Context

CATH Clusters

Superfamily Isoleucyl-tRNA Synthetase; Domain 1
Functional Family Probable methionine--tRNA ligase, mitochondrial

Enzyme Information

6.1.1.10
Methionine--tRNA ligase.
based on mapping to UniProt P00959
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl- tRNA(Met).
-!- In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.

UniProtKB Entries (1)

P00959
SYM_ECOLI
Escherichia coli K-12
Methionine--tRNA ligase

PDB Structure

PDB 1PFU
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.
Crepin, T., Schmitt, E., Mechulam, Y., Sampson, P.B., Vaughan, M.D., Honek, J.F., Blanquet, S.
J.Mol.Biol.