CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Shikimate dehydrogenase (NADP(+))

Enzyme Information

1.1.1.25
Shikimate dehydrogenase.
based on mapping to UniProt P43876
Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
-!- NAD(+) cannot replace NADP(+). -!- In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.

UniProtKB Entries (1)

P43876
AROE_HAEIN
Haemophilus influenzae Rd KW20
Shikimate dehydrogenase (NADP(+))

PDB Structure

PDB 1P74
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode
Ye, S., von Delft, F., Brooun, A., Knuth, M.W., Swanson, R.V., McRee, D.E.
J.Bacteriol.