CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Inositol-3-phosphate synthase 1

Enzyme Information

5.5.1.4
Inositol-3-phosphate synthase.
based on mapping to UniProt P11986
D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.
-!- The NAD(+) dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1; finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form.

UniProtKB Entries (1)

P11986
INO1_YEAST
Saccharomyces cerevisiae S288C
Inositol-3-phosphate synthase

PDB Structure

PDB 1P1K
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of NAD(+)- and NADH-bound 1-l-myo-inositol 1-phosphate synthase.
Jin, X., Geiger, J.H.
Acta Crystallogr.,Sect.D