CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Aspartate aminotransferase

Enzyme Information

2.6.1.1
Aspartate transaminase.
based on mapping to UniProt P00508
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
-!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. -!- This activity can be formed from EC 2.6.1.57 by controlled proteolysis.
2.6.1.7
Kynurenine--oxoglutarate transaminase.
based on mapping to UniProt P00508
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
-!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.

UniProtKB Entries (1)

P00508
AATM_CHICK
Gallus gallus
Aspartate aminotransferase, mitochondrial

PDB Structure

PDB 1OXO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase.
Markovic-Housley, Z., Schirmer, T., Hohenester, E., Khomutov, A.R., Khomutov, R.M., Karpeisky, M.Y., Sandmeier, E., Christen, P., Jansonius, J.N.
Eur.J.Biochem.