CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.65
Macrophage elastase.
based on mapping to UniProt P39900
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
-!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P39900
MMP12_HUMAN
Homo sapiens
Macrophage metalloelastase

PDB Structure

PDB 1OS2
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
X-ray Structures of Binary and Ternary Enzyme-Product-Inhibitor Complexes of Matrix Metalloproteinases
Bertini, I., Calderone, V., Fragai, M., Luchinat, C., Mangani, S., Terni, B.
Angew.Chem.Int.Ed.Engl.