CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Serine protease 37

Enzyme Information

3.4.21.78
Granzyme A.
based on mapping to UniProt P12544
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|- Xaa- in small molecule substrates.
-!- From cytotoxic T lymphocyte granules. -!- The human enzyme does not cleave Phe-|-Xaa. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P12544
GRAA_HUMAN
Homo sapiens
Granzyme A

PDB Structure

PDB 1ORF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.
Bell, J.K., Goetz, D.H., Mahrus, S., Harris, J.L., Fletterick, R.J., Craik, C.S.
Nat.Struct.Biol.