CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Complement factor D

Enzyme Information

3.4.21.78
Granzyme A.
based on mapping to UniProt P12544
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|- Xaa- in small molecule substrates.
-!- From cytotoxic T lymphocyte granules. -!- The human enzyme does not cleave Phe-|-Xaa. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P12544
GRAA_HUMAN
Homo sapiens
Granzyme A

PDB Structure

PDB 1ORF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.
Bell, J.K., Goetz, D.H., Mahrus, S., Harris, J.L., Fletterick, R.J., Craik, C.S.
Nat.Struct.Biol.