CATH Classification

Domain Context

CATH Clusters

Superfamily NADH Oxidase
Functional Family Oxygen-insensitive NAD(P)H nitroreductase

Enzyme Information

1.5.1.34
6,7-dihydropteridine reductase.
based on mapping to UniProt P38489
A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H.
-!- The substrate is the quinonoid form of dihydropteridine. -!- Not identical with EC 1.5.1.3. -!- Formerly EC 1.6.99.7 and EC 1.6.99.10.
1.-.-.-
Oxidoreductases.
based on mapping to UniProt P38489

UniProtKB Entries (1)

P38489
NFSB_ECOLI
Escherichia coli K-12
Oxygen-insensitive NAD(P)H nitroreductase

PDB Structure

PDB 1OON
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S.
J.Med.Chem.