CATH Classification
Domain Context
CATH Clusters
| Superfamily | Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A |
| Functional Family | Exostosin-like glycosyltransferase 2 |
Enzyme Information
| 2.4.1.223 |
Glucuronosyl-galactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.
based on mapping to UniProt Q9ES89
UDP-N-acetyl-alpha-D-glucosamine + [protein]-3-O-(beta-D-GlcA-(1->3)- beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.
-!- Enzyme involved in the initiation of heparin and heparan sulfate synthesis, transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core. -!- Apparently products of both the human EXTL2 and EXTL3 genes can catalyze this reaction. -!- In Caenorhabditis elegans, the product of the rib-2 gene displays this activity as well as that of EC 2.4.1.224.
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UniProtKB Entries (1)
| Q9ES89 |
EXTL2_MOUSE
Mus musculus
Exostosin-like 2
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PDB Structure
| PDB | 1ON8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis
J.Biol.Chem.
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