CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Ferredoxin-dependent glutamate synthase, chloroplastic

Enzyme Information

1.4.7.1
Glutamate synthase (ferredoxin).
based on mapping to UniProt P55038
2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H(+).
-!- The protein is composed of two domains, one hydrolyzing L-glutamine to NH(3) and L-glutamate (cf. EC 3.5.1.2), the other combining the produced NH(3) with 2-oxoglutarate to produce a second molecule of L-glutamate. -!- The NH(3) is channeled through a 24 A channel in the active protein. -!- No hydrolysis of glutamine takes place without ferredoxin and 2-oxoglutarate being bound to the protein.

UniProtKB Entries (1)

P55038
GLTS_SYNY3
Synechocystis sp. PCC 6803 substr. Kazusa
Ferredoxin-dependent glutamate synthase 2

PDB Structure

PDB 1OFE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Active Conformation of Glutamate Synthase and its Binding to Ferredoxin
Van Den Heuvel, R.H.H., Svergun, D.I., Petoukhov, M.V., Coda, A., Curti, B., Ravasio, S., Vanoni, M.A., Mattevi, A.
J.Mol.Biol.