CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family Quinone oxidoreductase yhdH

Enzyme Information

1.3.1.84
Acrylyl-CoA reductase (NADPH).
based on mapping to UniProt P26646
Propanoyl-CoA + NADP(+) = acrylyl-CoA + NADPH.
-!- Catalyzes a step in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea. -!- The reaction is catalyzed in the opposite direction to that shown. -!- The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA. -!- Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16.

UniProtKB Entries (1)

P26646
ACUI_ECOLI
Escherichia coli K-12
Probable acrylyl-CoA reductase AcuI

PDB Structure

PDB 1O89
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the Escherichia Coli Yhdh, a Putative Quinone Oxidoreductase
Sulzenbacher, G., Roig-Zamboni, V., Pagot, F., Grisel, S., Salamoni, A., Valencia, C., Campanacci, V., Vincentelli, R., Tegoni, M., Eklund, H., Cambillau, C.
Acta Crystallogr.,Sect.D