CATH Classification

Domain Context

CATH Clusters

Superfamily 1.50.10.20
Functional Family

Enzyme Information

5.4.99.17
Squalene--hopene cyclase.
based on mapping to UniProt P33247
Squalene = hop-22(29)-ene.
-!- The enzyme also produces the cyclization product hopan-22-ol by addition of water (cf. EC 4.2.1.129). -!- Hopene and hopanol are formed at a constant ratio of 5:1.
4.2.1.129
Squalene--hopanol cyclase.
based on mapping to UniProt P33247
Hopan-22-ol = squalene + H(2)O.
-!- The enzyme produces the cyclization products hopene (cf. EC 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1.

UniProtKB Entries (1)

P33247
SQHC_ALIAD
Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446
Squalene--hopene cyclase

PDB Structure

PDB 1O6R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
Lenhart, A., Reinert, D.J., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
J.Med.Chem.