CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.38
Malate dehydrogenase (oxaloacetate-decarboxylating).
based on mapping to UniProt P27443
(1) (S)-malate + NAD(+) = pyruvate + CO(2) + NADH. (2) Oxaloacetate = pyruvate + CO(2).
-!- Unlike EC 1.1.1.39, this enzyme can also decarboxylate oxaloacetate, cf. EC 1.1.1.40.

UniProtKB Entries (1)

P27443
MAOM_ASCSU
Ascaris suum
NAD-dependent malic enzyme, mitochondrial

PDB Structure

PDB 1O0S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic studies on Ascaris suum NAD-malic enzyme bound to reduced cofactor and identification of an effector site.
Rao, G.S., Coleman, D.E., Karsten, W.E., Cook, P.F., Harris, B.G.
J.Biol.Chem.