CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00524
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00524
SRC_RSVSA
Rous sarcoma virus (strain Schmidt-Ruppin A)
Tyrosine-protein kinase transforming protein Src

PDB Structure

PDB 1NZV
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and Thermodynamic Basis for the Interaction of the Src SH2 domain with the Activated form of the PDGF beta-receptor
Lubman, O.Y., Waksman, G.
J.Mol.Biol.